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Journal of Biomedical Optics

Determination of the optical properties of anisotropic biological media using an isotropic diffusion model
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Paper Abstract

We investigate anisotropic light propagation in biological tissue in steady-state and time domains. Monte Carlo simulations performed for tissue that consists of aligned cylindrical and spherical scatterers show that steady-state and time-resolved reflectance depends strongly on the measurement direction relative to the alignment of the cylinder axis. We examine the determination of optical properties using an isotropic diffusion model and find that in the time domain, in contrast to steady-state spatially resolved reflectance measurements, the obtained absorption coefficient does not depend on the measurement direction and is close to the true value. Contrarily, the derived reduced scattering coefficient depends strongly on the measurement direction in both domains. Measurements of the steady-state and time-resolved reflectance from bovine tendon confirm the theoretical findings.

Paper Details

Date Published: 1 January 2007
PDF: 9 pages
J. Biomed. Opt. 12(1) 014026 doi: 10.1117/1.2709864
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
Alwin Kienle, Univ. Ulm (Germany)
Corinna Wetzel, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Andrea Li Bassi, Politecnico di Milano (Italy)
Daniela Comelli, Politecnico di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)


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