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Journal of Biomedical Optics • Open Access

Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer
Author(s): Roger J. Zemp; Rachel Bitton; K. Kirk Shung; Meng-Lin Li; George Stoica; Lihong V. Wang

Paper Abstract

Visualization of microvascular networks could provide new information about function and disease. We demonstrate the capabilities of a 30-MHz ultrasound array system for photoacoustic microscopy of small (≤300 μm) vessels in a rat. 3D images obtained by translating the array in the elevation direction are compared with photographs of excised skin. The system is shown to have 100-μm lateral resolution, 25-μm axial resolution, and 3-mm imaging depth. To our knowledge this is the first report on photoacoustic microscopy of the microvasculature with a high-frequency array transducer. It is anticipated that the system can be used for studying and diagnosing a number of diseases including cancer, atherosclerosis, dermatological disorders, and peripheral microvascular complications in diabetes.

Paper Details

Date Published: 1 January 2007
PDF: 3 pages
J. Biomed. Opt. 12(1) 010501 doi: 10.1117/1.2709850
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
Roger J. Zemp, Washington Univ. in St. Louis (United States)
Rachel Bitton, Univ. of Southern California (United States)
K. Kirk Shung, Univ. of Southern California (United States)
Meng-Lin Li, National Tsing Hua Univ. (Taiwan)
George Stoica, Texas A&M Univ. (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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