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Journal of Biomedical Optics

Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model
Author(s): InSeok Seo; Joon Shik You; Carole Hayakawa; Vasan Venugopalan
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Paper Abstract

The use of perturbation and differential Monte Carlo (pMC/dMC) methods in conjunction with nonlinear optimization algorithms were proposed recently as a means to solve inverse photon migration problems in regionwise heterogeneous turbid media. We demonstrate the application of pMC/dMC methods for the recovery of optical properties in a two-layer extended epithelial tissue model from experimental measurements of spatially resolved diffuse reflectance. The results demonstrate that pMC/dMC methods provide a rapid and accurate approach to solve two-region inverse photon migration problems in the transport regime, that is, on spatial scales smaller than a transport mean free path and in media where optical scattering need not dominate absorption. The pMC/dMC approach is found to be effective over a broad range of absorption (50 to 400%) and scattering (70 to 130%) perturbations. The recovery of optical properties from spatially resolved diffuse reflectance measurements is examined for different sets of source-detector separation. These results provide some guidance for the design of compact fiber-based probes to determine and isolate optical properties from both epithelial and stromal layers of superficial tissues.

Paper Details

Date Published: 1 January 2007
PDF: 15 pages
J. Biomed. Opt. 12(1) 014030 doi: 10.1117/1.2697735
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
InSeok Seo, Univ. of California/Irvine (United States)
Joon Shik You, Beckman Laser Institute and Medical Clinic (United States)
Carole Hayakawa, Univ. of California/Irvine (United States)
Vasan Venugopalan, Univ. of California/Irvine (United States)


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