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Journal of Biomedical Optics

Diffusion model for iontophoresis measured by laser-Doppler perfusion flowmetry, applied to normal and preeclamptic pregnancies
Author(s): Frits F. M. de Mul; Judith Blaauw; Jan G. Aarnoudse; Andries J. Smit; Gerhard Rakhorst
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Paper Abstract

We present a physical model to describe iontophoresis time recordings. The model is a combination of monodimensional material diffusion and decay, probably due to transport by blood flow. It has four adjustable parameters, the diffusion coefficient, the decay constant, the height of the response, and the shot saturation constant, a parameter representing the relative importance of subsequent shots (in case of saturation). We test the model with measurements of blood perfusion in the capillary bed of the fingers of women who recently had preeclampsia and in women with a history of normal pregnancy. From the fits to the measurements, we conclude that the model provides a useful physical description of the iontophoresis process.

Paper Details

Date Published: 1 January 2007
PDF: 9 pages
J. Biomed. Opt. 12(1) 014032 doi: 10.1117/1.2671053
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
Frits F. M. de Mul, Groningen Univ. Medical Ctr. (Netherlands)
Judith Blaauw, Groningen Univ. Medical Ctr. (Netherlands)
Jan G. Aarnoudse, Univ. of Groningen (Netherlands)
Andries J. Smit, Groningen Univ. Medical Ctr. (Netherlands)
Gerhard Rakhorst, Groningen Univ. Medical Ctr. (Netherlands)

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