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Journal of Biomedical Optics

In vivo spectroscopic ellipsometry measurements on human skin
Author(s): Danny Chan; Benjamin Schulz; Kathrin Gloystein; Heike Hedwig Muller; Michael Rübhausen
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Paper Abstract

We study the behavior of optical properties of human skin across its layers. We describe ellipsometric measurements for spectrally resolved in vivo investigations of biological tissue. We show in vivo measurements on human skin of the ellipsometric parameters Ψ and Δ, which describe the change in polarization of light on reflection on a sample. A tape-stripping study reveals the depth profile of the ellipsometric parameters into the stratum corneum. The depth profile shows an increase in both quantities with increased depth. Analyzing the development of Ψ on the number of strips using an exponential function shows a steady state after approximately 2 μm. The evolution of Ψ and Δ can be described using a morphological model containing an effective medium approximation accounting for the water content of the skin, surface roughnesses of the corneocytes, as well as the alternating cell and lipid layers.

Paper Details

Date Published: 1 January 2007
PDF: 6 pages
J. Biomed. Opt. 12(1) 014023 doi: 10.1117/1.2435703
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
Danny Chan, Univ. Hamburg (Germany)
Benjamin Schulz, Univ. Hamburg (Germany)
Kathrin Gloystein, Univ. Hamburg (Germany)
Heike Hedwig Muller, Univ. Hamburg (Germany)
Michael Rübhausen, Univ. Hamburg (Germany)

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