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Journal of Biomedical Optics

Snapshot hyperspectral imaging in ophthalmology
Author(s): William R. Johnson; Daniel W. Wilson; Wolfgang Fink; Mark S. Humayun; Gregory H. Bearman
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Paper Abstract

Retinal imaging spectroscopy can provide functional maps using chromophore spectra. For example, oxygen saturation maps show ischemic areas from diabetes and venous occlusions. Obtaining retinal spatial-spectral data has been difficult due to saccades and long data acquisition times (>5 s). We present a snapshot imaging spectrometer with far-reaching applicability that acquires a complete spatial-spectral image cube in ~3 ms from 450 to 700 nm with 50 bands, eliminating motion artifacts and pixel misregistration. Current retinal spectral imaging approaches are incapable of true snapshot operation over a wide spectral range with a large number of spectral bands. Coupled to a fundus camera, the instrument returns true color retinal images for comparison to standard fundus images and for image validation while the patient is still dilated. Oxygen saturation maps were obtained with a three-wavelength algorithm: for healthy subjects arteries were ~95% and veins 30 to 35% less. The instrument is now undergoing clinical trials.

Paper Details

Date Published: 1 January 2007
PDF: 7 pages
J. Biomed. Opt. 12(1) 014036 doi: 10.1117/1.2434950
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
William R. Johnson, Jet Propulsion Lab. (United States)
Daniel W. Wilson, Jet Propulsion Lab. (United States)
Wolfgang Fink, California Institute of Technology (United States)
Mark S. Humayun, Univ. of Southern California (United States)
Gregory H. Bearman, Jet Propulsion Lab. (United States)

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