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Journal of Biomedical Optics

Time-resolved imaging of optical coefficients through murine chest cavities
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Paper Abstract

As small animal optical imaging and tomography are gaining popularity for interrogating functional and molecular events in vivo, it becomes increasingly necessary to gain knowledge of the optical properties of the species investigated to better understand and describe photon propagation through their tissues. To achieve characterization of the spatial variation of average optical properties through murine chest cavities, time- and spatially resolved measurements of femto-second laser pulse transmission are performed through mice using a high-speed gated image intensifier. Application of time-resolved diffusion theory for finite slab geometry is first confirmed on phantoms and then applied to in vivo measurements for spatially resolving and quantifying mouse optical properties. Photon transmission images through mouse chest cavities are further obtained at different time gates to visualize the spatial variation observed and confirm the optical coefficient patterns calculated.

Paper Details

Date Published: 1 November 2006
PDF: 7 pages
J. Biomed. Opt. 11(6) 064017 doi: 10.1117/1.2400702
Published in: Journal of Biomedical Optics Volume 11, Issue 6
Show Author Affiliations
Mark J. Niedre, Massachusetts General Hospital (United States)
Gordon M. Turner, Massachusetts General Hospital (United States)
Vasilis Ntziachristos, Massachusetts General Hospital (United States)


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