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Journal of Biomedical Optics

Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling
Author(s): Stoyan Tanev; Valery V. Tuchin; Paul Paddon
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Paper Abstract

Pilot results on the application of the finite-difference time-domain (FDTD) approach for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells are presented. We focus on two different scenarios considering single biological cells containing (1) cytoplasm, nucleus, and membrane and (2) cytoplasm, nucleus, gold nanoparticles, and membrane. To the best of our knowledge, this is the first time the cell membrane thickness and gold nanoparticle effects on the forward scattered light from biological cells are discussed. The applicability and the potential of the FDTD approach for studying optical immersion technique enhanced bioimaging is demonstrated.

Paper Details

Date Published: 1 November 2006
PDF: 6 pages
J. Biomed. Opt. 11(6) 064037 doi: 10.1117/1.2400239
Published in: Journal of Biomedical Optics Volume 11, Issue 6
Show Author Affiliations
Stoyan Tanev, Carleton Univ. (Canada)
Valery V. Tuchin, Saratov State Univ. (Russia)
Paul Paddon, Lumerical Solutions, Inc. (Canada)

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