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Journal of Biomedical Optics

Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia
Author(s): Lindsey A. Nelson; John C. McCann; Andreas W. Loepke; Jun Wu; Baruch Ben-Dor; Dean C. Kurth
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Paper Abstract

Detection of cerebral hypoxia-ischemia in infants remains problematic, as current monitors in clinical practice are impractical, insensitive, or nonspecific. Our study develops a multiwavelength spatial domain construct for near-infrared spectroscopy (NIRS) to detect cerebral hypoxia-ischemia and evaluates the construct in several models. The NIRS probe contains photodiode detectors 2, 3, and 4 cm from a three-wavelength, light-emitting diode. A construct determines cerebral O2 saturation based on spatial domain principles. Device performance and construct validity are examined in in-vitro models simulating the brain, and in piglets subjected to hypoxia, hypoxia-ischemia, and hyperoxic conditions using a weighted average of arterial and cerebral venous O2 saturation measured by CO-oximetry. The results in the brain models verify key equations in the construct and demonstrate reliable performance of the device. In piglets, the device measures cerebral O2 saturation with bias ±4% and precision ±8%. In conclusion, this NIRS device accurately detects cerebral hypoxia-ischemia and is of a design that is practical for clinical application.

Paper Details

Date Published: 1 November 2006
PDF: 8 pages
J. Biomed. Opt. 11(6) 064022 doi: 10.1117/1.2393251
Published in: Journal of Biomedical Optics Volume 11, Issue 6
Show Author Affiliations
Lindsey A. Nelson, Cincinnati Children's Hospital Medical Ctr. (United States)
John C. McCann, Cincinnati Children's Hospital Medical Ctr. (United States)
Andreas W. Loepke, Cincinnati Children's Hospital Medical Ctr. (United States)
Jun Wu, Cincinnati Children's Hospital Medical Ctr. (United States)
Baruch Ben-Dor
Dean C. Kurth, Cincinnati Children's Hospital Medical Ctr. (United States)

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