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Journal of Biomedical Optics

Noise contribution to the correlation between temperature-induced localized reflectance of diabetic skin and blood glucose
Author(s): Michael G. Lowery; Brenda Calfin; Shu-Jen Yeh; Tao Doan; Eric B. Shain; Charles F. Hanna; Ronald Hohs; Stanislaw Kantor; John Lindberg; Omar S. Khalil
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Paper Abstract

We used the effect of temperature on the localized reflectance of human skin to assess the role of noise sources on the correlation between temperature-induced fractional change in optical density of human skin (ODT) and blood glucose concentration [BG]. Two temperature-controlled optical probes at 30°C contacted the skin, one was then cooled by –10°C; the other was heated by +10°C. ODT upon cooling or heating was correlated with capillary [BG] of diabetic volunteers over a period of three days. Calibration models in the first two days were used to predict [BG] in the third day. We examined the conditions where the correlation coefficient (R2) for predicting [BG] in a third day ranked higher than R2 values resulting from fitting permutations of randomized [BG] to the same ODT values. It was possible to establish a four-term linear regression correlation between ODT upon cooling and [BG] with a correlation coefficient higher than that of an established noise threshold in diabetic patients that were mostly females with less than 20 years of diabetes duration. The ability to predict [BG] values with a correlation coefficient above biological and body-interface noise varied between the cases of cooling and heating.

Paper Details

Date Published: 1 September 2006
PDF: 8 pages
J. Biomed. Opt. 11(5) 054029 doi: 10.1117/1.2360529
Published in: Journal of Biomedical Optics Volume 11, Issue 5
Show Author Affiliations
Michael G. Lowery, Abbott Labs. (United States)
Brenda Calfin, Abbott Labs. (United States)
Shu-Jen Yeh, Abbott Labs. (United States)
Tao Doan, Abbott Labs. (United States)
Eric B. Shain, Abbott Labs. (United States)
Charles F. Hanna, Abbott Labs. (United States)
Ronald Hohs, Abbott Labs. (United States)
Stanislaw Kantor, Abbott Labs. (United States)
John Lindberg, Abbott Labs. (United States)
Omar S. Khalil, Abbott Labs. (United States)

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