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Journal of Biomedical Optics

Doppler optical coherence microscopy for studies of cochlear mechanics
Author(s): Stanley S. Hong; Dennis M. Freeman
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Paper Abstract

The possibility of measuring subnanometer motions with micron scale spatial resolution in the intact mammalian cochlea using Doppler optical coherence microscopy (DOCM) is demonstrated. A novel DOCM system is described that uses two acousto-optic modulators to generate a stable 500-kHz heterodyne frequency. Images and motion measurements are obtained using phase-resolved analysis of the interference signal. The DOCM system permits imaging with micron-scale resolution and 85-dB sensitivity and motion measurements with 100-kHz bandwidth, directional discrimination, and 30-pm/Hz0.5 noise floor. Images and motion measurements are presented that demonstrate the ability to resolve motions of structures of interest in a mammalian cochlea in vitro including the basilar membrane, reticular lamina, tectorial membrane, and outer hair cells.

Paper Details

Date Published: 1 September 2006
PDF: 5 pages
J. Biomed. Opt. 11(5) 054014 doi: 10.1117/1.2358702
Published in: Journal of Biomedical Optics Volume 11, Issue 5
Show Author Affiliations
Stanley S. Hong, Massachusetts Institute of Technology (United States)
Dennis M. Freeman, Massachusetts Institute of Technology (United States)


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