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Journal of Biomedical Optics

In vivo high-speed imaging of individual cells in fast blood flow
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Paper Abstract

In vivo, label-free, high-speed (up to 10,000 with the potential for 40,000 frames per second), high-resolution (up to 300 nm) real-time continuous imaging with successive framing of circulating individual erythrocytes, leukocytes, and platelets in fast blood flow is developed. This technique, used in an animal model, reveals the extremely high dynamic deformability of erythrocytes in natural flow. Potential applications of this technique are discussed with focus on time-resolved monitoring of the cell deformation dynamics in the native biological environment, which may have diagnostic value for the early diagnosis of diseases.

Paper Details

Date Published: 1 September 2006
PDF: 4 pages
J. Biomed. Opt. 11(5) 054034 doi: 10.1117/1.2355666
Published in: Journal of Biomedical Optics Volume 11, Issue 5
Show Author Affiliations
Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (United States)
Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (United States)
Saratov State Univ. (Russia)
Yulian A. Menyaev, Univ. of Arkansas for Medical Sciences (United States)
Bauman Moscow State Technical Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)

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