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Journal of Biomedical Optics

Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
Author(s): Xin Wang; Brian W. Pogue; Shudong Jiang; Hamid Dehghani; Xiaomei Song; Subhadra Srinivasan; Ben A. Brooksby; Keith D. Paulsen; Christine A. Kogel; Steven P. Poplack; Wendy A. Wells
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Paper Abstract

A method for image reconstruction of the effective size and number density of scattering particles is discussed within the context of interpreting near-infrared (NIR) tomography images of breast tissue. An approach to use Mie theory to estimate the effective scattering parameters is examined and applied, given some assumptions about the index of refraction change expected in lipid membrane-bound scatterers. When using a limited number of NIR wavelengths in the reduced scattering spectra, the parameter extraction technique is limited to representing a continuous distribution of scatterer sizes, which is modeled as a simple exponentially decreasing distribution function. In this paper, image formation of effective scatterer size and number density is presented based on the estimation method. The method was evaluated with Intralipid phantom studies to demonstrate particle size estimation to within 9% of the expected value. Then the method was used in NIR patient images, and it indicates that for a cancer tumor, the effective scatterer size is smaller than the background breast values and the effective number density is higher. In contrast, for benign tumor patients, there is not a significant difference in effective scatterer size or number density between tumor and normal tissues. The method was used to interpret magnetic resonance imaging–coupled NIR images of adipose and fibroglandular tissues, and it indicated that the fibroglandular tissue has smaller effective scatterer size and larger effective number density than the adipose tissue does.

Paper Details

Date Published: 1 July 2006
PDF: 13 pages
J. Biomed. Opt. 11(4) 041106 doi: 10.1117/1.2342747
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Xin Wang, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Shudong Jiang, Dartmouth College (United States)
Hamid Dehghani, Dartmouth College (United States)
Xiaomei Song, Dartmouth College (United States)
Subhadra Srinivasan, Dartmouth College (United States)
Ben A. Brooksby, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)
Christine A. Kogel, Dartmouth Hitchcock Medical Ctr. (United States)
Steven P. Poplack, Dartmouth Hitchcock Medical Ctr. (United States)
Wendy A. Wells, Dartmouth Medical School (United States)

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