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Journal of Biomedical Optics

Angular measurements of light scattered by turbid chiral media using linear Stokes polarimeter
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Paper Abstract

The effects of turbid chiral media on light polarization are studied in different directions around the scattering samples using a refined linear Stokes polarimeter, which simplifies the signal analysis, and allows for the detailed investigations of scattered light. Because no moving parts are involved in a measurement at a specific detection direction, the determination accuracy of polarization states is increased. The results show that light depolarization increases with both turbidity and detection angle for low and moderately turbid samples; however, the angular dependence decreases with increasing turbidity. When the turbidity is increased to ~100 cm–1, the depolarization becomes higher in the forward than in the backward direction. Polarization sensitive Monte Carlo simulations are used to verify some experimental observations. The results also demonstrate that surviving linear polarization fraction and overall intensity are more sensitive to the increase of glucose concentration in backward than in the forward direction in highly turbid media, indicating that backward geometry may be preferable for potential glucose detection in a biomedical context. Comparison measurements with optically inactive glycerol suggest that the refractive index matching effect, and not the chiral nature of the solute, dominates the observed optical rotation engendered by glucose in highly turbid media.

Paper Details

Date Published: 1 July 2006
PDF: 10 pages
J. Biomed. Opt. 11(4) 041105 doi: 10.1117/1.2339134
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Xinxin Guo, Univ. of Toronto (Canada)
Michael Wood, Univ. of Toronto (Canada)
Alex I. Vitkin, Princess Margaret Hospital (Canada)


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