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Journal of Biomedical Optics

Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells
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Paper Abstract

Nanoshell-enhanced optical coherence tomography (OCT) is a novel technique with the potential for molecular imaging and improved disease detection. However, optimization of this approach will require a quantitative understanding of the influence of nanoshell parameters on detected OCT signals. In this study, OCT was performed at 1310 nm in water and turbid tissue-simulating phantoms to which nanoshells were added. The effect of nanoshell concentration, core diameter, and shell thickness on signal enhancement was characterized. Experimental results indicated trends that were consistent with predicted optical properties—a monotonic increase in signal intensity and attenuation with increasing shell and core size. Threshold concentrations for a 2-dB OCT signal intensity gain were determined for several nanoshell geometries. For the most highly backscattering nanoshells tested—291-nm core diameter, 25-nm shell thickness—a concentration of 109 nanoshells/mL was needed to produce this signal increase. Based on these results, we discuss various practical considerations for optimizing nanoshell-enhanced OCT. Quantitative experimental data presented here will facilitate optimization of OCT-based diagnostics and may also be relevant to other reflectance-based approaches as well.

Paper Details

Date Published: 1 July 2006
PDF: 8 pages
J. Biomed. Opt. 11(4) 041121 doi: 10.1117/1.2339071
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Anant Agrawal, U.S. Food and Drug Administration (United States)
Stanley Huang, Johns Hopkins Univ. (United States)
Alex Wei Han Lin, Rice Univ. (United States)
Min-Ho Lee, Rice Univ. (United States)
Jennifer Kehlet Barton, The Univ. of Arizona (United States)
Rebekah Anna Drezek, Rice Univ. (United States)
Joshua Pfefer, U.S. Food and Drug Administration (United States)

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