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Journal of Biomedical Optics

Fourier-domain biophotoacoustic subsurface depth selective amplitude and phase imaging of turbid phantoms and biological tissue
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Paper Abstract

A novel photothermoacoustic imaging modality utilizing a frequency-swept (chirped) intensity-modulated laser source and coherent frequency domain signal processing ("biophotoacoustics") was introduced for noninvasive imaging of biological tissues. The developed frequency-domain imaging system takes advantage of linear frequency modulation waveforms to relate depth of tissue chromophores to the frequency spectrum of the detected acoustic response and of a narrow signal detection bandwidth to improve signal-to-noise ratio (SNR). Application of frequency-domain photothermoacoustic (FD-PTA) imaging was demonstrated using turbid phantoms and ex-vivo specimens of chicken breast with embedded absorbing inclusions simulating tumors.

Paper Details

Date Published: 1 July 2006
PDF: 10 pages
J. Biomed. Opt. 11(4) 044006 doi: 10.1117/1.2337290
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Sergey A. Telenkov, Imaging Diagnostic Systems, Inc. (United States)
Andreas Mandelis, Univ. of Toronto (Canada)


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