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Journal of Biomedical Optics

Temperature-dependent optical properties of individual vascular wall components measured by optical coherence tomography
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Paper Abstract

Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n and the attenuation coefficient µt using optical coherence tomography (OCT) of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compare measurements at room and body temperatures. A decrease of n and µt is observed in all samples, with the most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex-vivo experimental results, especially for structures with high lipid content, this effect should be taken into account.

Paper Details

Date Published: 1 July 2006
PDF: 6 pages
J. Biomed. Opt. 11(4) 041120 doi: 10.1117/1.2333613
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Freek J. van der Meer, Academisch Medisch Ctr. (Netherlands)
Dirk J. Faber, Academisch Medisch Ctr. (Netherlands)
Inci F. Cilesiz, Istanbul Teknik Üniv. (Turkey)
Martin J. C. van Gemert, Academic Medical Ctr. (Netherlands)
Ton G. van Leeuwen, Univ. Twente (Netherlands)

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