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Journal of Biomedical Optics

Investigation of light propagation models to determine the optical properties of tissue from interstitial frequency domain fluence measurements
Author(s): Heping Xu; Thomas J. Farrell; Michael S. Patterson
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Paper Abstract

Four models, standard diffusion approximation (SDA), single Monte Carlo (SMC), delta-P1, and isotropic similarity (ISM), are developed and evaluated as forward calculation tools in the estimation of tissue optical properties. The inverse calculation uses the ratio of the fluences and phase difference at two locations close to an intensity modulated isotropic source to recover the reduced scattering coefficient µs and the absorption coefficient µa. Diffusion theory allows recovery of optical properties (OPs) within 5% for media with µs/µa>10. The performance of the delta-P1 model is similar to SDA, with limited enhanced accuracy. The collimation approximation may limit the use of the delta-P1 model for spherical geometry, and/or the fluence may not be accurately calculated by this model. The SMC model is the best, recovering OPs within 10% regardless of the albedo. However, the necessary restriction of the searched OPs space is inconvenient. The performance of ISM is similar to that of diffusion theory for media with µs/µa>10, and better for 1<µs/µa<10, i.e., determines absorption within 5% and reduced scattering within 20%. In practice, satisfactory estimates (within 5 to 10%) can be achieved using SDA to recover µs and ISM to recover µa for media with µs/µa>5.

Paper Details

Date Published: 1 July 2006
PDF: 18 pages
J. Biomed. Opt. 11(4) 041104 doi: 10.1117/1.2241609
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Heping Xu, Juravinski Cancer Ctr. (Canada)
Thomas J. Farrell, Juravinski Cancer Ctr. (Canada)
Michael S. Patterson, Juravinski Cancer Ctr. (Canada)

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