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Journal of Biomedical Optics

Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening
Author(s): Young L. Kim; Yang Liu; Vladimir M. Turzhitsky; Hemant K. Roy; Ramesh K. Wali; Hariharan Subramanian; Prabhakar Pradhan; Vadim Backman
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Paper Abstract

The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).

Paper Details

Date Published: 1 July 2006
PDF: 10 pages
J. Biomed. Opt. 11(4) 041125 doi: 10.1117/1.2236292
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Young L. Kim, Northwestern Univ. (United States)
Yang Liu, Northwestern Univ. (United States)
Vladimir M. Turzhitsky, Northwestern Univ. (United States)
Hemant K. Roy, Northwestern Univ. (United States)
Ramesh K. Wali, Northwestern Univ. (United States)
Hariharan Subramanian, Northwestern Univ. (United States)
Prabhakar Pradhan, Northwestern Univ. (United States)
Vadim Backman, Northwestern Univ. (United States)

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