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Journal of Biomedical Optics • Open Access

Collagen solubility correlates with skin optical clearing
Author(s): Jason Hirshburg; Bernard Choi; J. Stuart Nelson; Alvin T. Yeh

Paper Abstract

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

Paper Details

Date Published: 1 July 2006
PDF: 3 pages
J. Biomed. Opt. 11(4) 040501 doi: 10.1117/1.2220527
Published in: Journal of Biomedical Optics Volume 11, Issue 4
Show Author Affiliations
Jason Hirshburg, Texas A&M Univ. (United States)
Bernard Choi, Univ. of California/Irvine (United States)
J. Stuart Nelson, Univ. of California/Irvine (United States)
Alvin T. Yeh, Texas A&M Univ. (United States)

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