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Journal of Biomedical Optics • Open Access

Photothermally induced delayed tissue death
Author(s): Jeffrey M. Gordon; Ruthy Shaco-Levy; Daniel Feuermann; Mahmoud M. Huleihil; Solly Mizrahi

Paper Abstract

We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.

Paper Details

Date Published: 1 May 2006
PDF: 3 pages
J. Biomed. Opt. 11(3) 030504 doi: 10.1117/1.2210948
Published in: Journal of Biomedical Optics Volume 11, Issue 3
Show Author Affiliations
Jeffrey M. Gordon, Ben-Gurion Univ. of the Negev (Israel)
Ruthy Shaco-Levy, Ben-Gurion Univ. of the Negev (Israel)
Daniel Feuermann, Ben-Gurion Univ. of the Negev (Israel)
Mahmoud M. Huleihil, Ben-Gurion Univ. of the Negev (Israel)
Solly Mizrahi, Ben-Gurion Univ. of the Negev (Israel)

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