Share Email Print
cover

Journal of Biomedical Optics

Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment
Author(s): Hee-Cheol Kim; Sebastian Härtner; Martin Behe; Thomas M. Behr; Norbert A. Hampp
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Tens of millions of cataract surgeries are done every year and the number is increasing heavily. Posterior capsule opacification is the major postoperative complication with an incidence of 10 to 50% within 5 years, depending on the age of the patient. We present a novel approach for secondary cataract treatment in a noninvasive manner. Photochemically triggered drug release from a polymer enables repeated drug applications for cataract treatment years after implantation of the intraocular lens, just when needed. However, light in the visible spectral range must pass through the lens but must not induce drug release. We demonstrate that two-photon absorption photochemistry is a powerful tool to overcome this problem. With wavelengths in the visible regime, a photochemical reaction that requires energies in the UV is triggered. The high intensities needed for this process never occur in any lighting condition in daily lives, but may be easily obtained with focused laser beams routinely used in ophthalmology. The properties of the therapeutic system are specified and the function is demonstrated by in-vitro cell tests. Noninvasive multidose photochemically triggered drug release from implanted intraocular lenses carrying a drug depot may be a therapeutic as well as an economic choice to established treatments of secondary cataracts.

Paper Details

Date Published: 1 May 2006
PDF: 9 pages
J. Biomed. Opt. 11(3) 034024 doi: 10.1117/1.2209564
Published in: Journal of Biomedical Optics Volume 11, Issue 3
Show Author Affiliations
Hee-Cheol Kim, Philipps-Univ. Marburg (Germany)
Sebastian Härtner, Philipps-Univ. Marburg (Germany)
Martin Behe, Philipps-Univ. Marburg (Germany)
Thomas M. Behr, Philipps-Univ. Marburg (Germany)
Norbert A. Hampp, Philipps-Univ. Marburg (Germany)


© SPIE. Terms of Use
Back to Top