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Journal of Biomedical Optics

Changes in nuclei and peritumoral collagen within nodular basal cell carcinomas via confocal micro-Raman spectroscopy
Author(s): Michael A. Short; Harvey Lui; David I. McLean; Haishan Zeng; Abdulmajeed Alajlan; Xiao K. Chen
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Paper Abstract

Confocal micro-Raman spectroscopy is used to probe the nuclei of normal human epidermal cells and epidermally derived cancer cells from nodular basal cell carcinomas. Clear differences are seen between the spectra. The nuclei of tumor cells appear to have different contributions from nucleic acids, histones, and proteins with an actin-like spectrum than those of normal epidermal cells. Changes in the contribution of DNA to the spectra are consistent with the staining of conventional histopathologic specimens. We also obtain spectra of the dermis, where it is found that the dermis close to tumor boundaries is not simply deficient in collagen, but shows signs of structural changes as well.

Paper Details

Date Published: 1 May 2006
PDF: 9 pages
J. Biomed. Opt. 11(3) 034004 doi: 10.1117/1.2209549
Published in: Journal of Biomedical Optics Volume 11, Issue 3
Show Author Affiliations
Michael A. Short, Simon Fraser Univ. (Canada)
Harvey Lui, The Univ. of British Columbia (Canada)
David I. McLean, The Univ. of British Columbia (Canada)
Haishan Zeng, British Columbia Cancer Agency (Canada)
Abdulmajeed Alajlan, The Univ. of British Columbia (Canada)
Xiao K. Chen, Simon Fraser Univ. (Canada)


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