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Journal of Biomedical Optics

Simple device for the direct visualization of oral-cavity tissue fluorescence
Author(s): Pierre Mark Lane; Terence Gilhuly; Peter D. Whitehead; Haishan Zeng; Catherine Poh; Samson Ng; Michelle Williams; Lewei Zhang; Miriam Rosin; Calum E. MacAulay
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Paper Abstract

Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light (400 to 460 nm) is employed to excite green-red fluorescence from fluorophores in the oral tissues. Tissue fluorescence is viewed directly along an optical axis collinear with the axis of excitation to reduce inter- and intraoperator variability. This robust, field-of-view device enables the direct visualization of fluorescence in the context of surrounding normal tissue. Results from a pilot study of 44 patients are presented. Using histology as the gold standard, the device achieves a sensitivity of 98% and specificity of 100% when discriminating normal mucosa from severe dysplasia/carcinoma in situ (CIS) or invasive carcinoma. We envisage this device as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation.

Paper Details

Date Published: 1 March 2006
PDF: 7 pages
J. Biomed. Opt. 11(2) 024006 doi: 10.1117/1.2193157
Published in: Journal of Biomedical Optics Volume 11, Issue 2
Show Author Affiliations
Pierre Mark Lane, BC Cancer Agency (Canada)
Terence Gilhuly, LED Medical Diagnostics Inc. (Canada)
Peter D. Whitehead, LED Medical Diagnostics Inc. (Canada)
Haishan Zeng, British Columbia Cancer Agency (Canada)
Catherine Poh, The Univ. of British Columbia (Canada)
Samson Ng, The Univ. of British Columbia (Canada)
Michelle Williams, BC Cancer Agency (Canada)
Lewei Zhang, The Univ. of British Columbia (Canada)
Miriam Rosin, Simon Fraser Univ. (Canada)
Calum E. MacAulay, The BC Cancer Research Ctr. (Canada)

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