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Journal of Biomedical Optics

Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons
Author(s): Alec M. Degrand; Stephen J. Lomnes; Deborah S. Lee; Matthew Pietrzykowski; Shunsuke Ohnishi; Timothy Morgan; Andrew Gogbashian; Rita G. Laurence; John V. Frangioni
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Paper Abstract

We demonstrate how to construct calibrated, stable, and inexpensive tissue-like phantoms for near-IR (NIR) fluorescence imaging applications. The bulk phantom material is composed of gelatin, intralipid, hemoglobin, and indocyanine green (ICG). Absorbance, scatter, background fluorescence, and texture can be tuned as desired. NIR fluorescent inclusions are comprised of ICG-labeled polystyrene divinylbenzene beads and Pam78-labeled hydroxyapatite crystals. The former mimic tumor masses of controllable size and contrast agent concentration, and the latter mimic microcalcifications in breast cancer. NIR-fluorescent inclusions can be positioned precisely in phantoms, with one or more regions having different optical properties, and their position can be verified independently using microcomputed tomography. We demonstrate how these phantoms can be used to calibrate and compare imaging systems, and to train surgeons to operate under NIR fluorescence image guidance.

Paper Details

Date Published: 1 January 2006
PDF: 10 pages
J. Biomed. Opt. 11(1) 014007 doi: 10.1117/1.2170579
Published in: Journal of Biomedical Optics Volume 11, Issue 1
Show Author Affiliations
Alec M. Degrand, Beth Israel Deaconess Medical Ctr. (United States)
Stephen J. Lomnes, GE Global Research (United States)
Deborah S. Lee, GE Global Research (United States)
Matthew Pietrzykowski, GE Global Research (United States)
Shunsuke Ohnishi, Beth Israel Deaconess Medical Ctr. (United States)
Timothy Morgan, GE Healthcare (United States)
Andrew Gogbashian, Brigham and Women's Hospital (United States)
Rita G. Laurence, Brigham and Women's Hospital (United States)
John V. Frangioni, Beth Israel Deaconess Medical Ctr. (United States)

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