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Journal of Biomedical Optics

Diffuse reflectance spectra of the palpebral conjunctiva and its utility as a noninvasive indicator of total hemoglobin
Author(s): John W. McMurdy; Gregory D. Jay; Selim Suner; Flor Trespalacios; Gregory P. Crawford
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Paper Abstract

The palpebral conjunctiva is an attractive location to qualitatively examine for the presence of anemia; however, this method of diagnosis has not been shown to be accurate. A spectroscopic examination of the palpebral conjunctiva enables the use of a quantitative parameter as a basis for diagnoses. Visible range diffuse reflectance spectra from the palpebral conjunctiva are examined from 30 patients and hemoglobin levels are extracted from these signatures using both a partial least-squares (PLS) multivariate regression model and a discrete spectral region model. Hemoglobin concentration derived from both these models is compared to an in vitro measurement of hemoglobin. Root mean squared errors of cross validation for the two analytical methods are 0.67 g/dL and 1.07 g/dL, respectively. Conjunctival reflectance spectra coupled with a PLS analysis achieve an enhanced specificity and sensitivity for anemia diagnoses over reported observational studies using the palpebral conjunctiva and achieve improved accuracy to other reported methods of noninvasive hemoglobin measurement.

Paper Details

Date Published: 1 January 2006
PDF: 8 pages
J. Biomed. Opt. 11(1) 014019 doi: 10.1117/1.2167967
Published in: Journal of Biomedical Optics Volume 11, Issue 1
Show Author Affiliations
John W. McMurdy, Brown Univ. (United States)
Gregory D. Jay, Rhode Island Hospital (United States)
Selim Suner, Rhode Island Hospital (United States)
Flor Trespalacios, Rhode Island Hospital (United States)
Gregory P. Crawford, Brown Univ. (United States)


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