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Journal of Biomedical Optics

Comparison of blood flow to the cutaneous temperature and redness after topical application of benzyl nicotinate
Author(s): Ute Jacobi; Marco Kaiser; Jürgen Koscielny; Rijk Schuetz; Martina C. Meinke; Wolfram Sterry; Jürgen Lademann
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Paper Abstract

The topical application of drugs, such as nicotinates, affects cutaneous blood flow. Such a biological response, which is dependent on the drug and the individual, can be measured noninvasively using laser Doppler flowmetry. We illustrate the kinetics of vasodilation caused by topically applied benzyl nicotinate using a new frequency-selective laser Doppler flowmeter. This flowmeter measures the blood flow in the superficial dermal plexus and the deeper lying larger capillaries simultaneously and indirectly by determining the flow velocity. Both sets of data are compared with the skin temperature and redness. Four biological parameters are measured consecutively on a skin area treated with gel containing benzyl nicotinate and on an untreated control area. A linear relationship between both blood flows is observed. However, no correlation is obtained between the microcirculation with either the cutaneous temperature or the redness. These results indicate the transport of the drug in the blood from the upper to the deeper capillaries. Cutaneous temperature and redness are unsuitable parameters to measure the kinetics of the blood flow after topical application of drugs.

Paper Details

Date Published: 1 January 2006
PDF: 6 pages
J. Biomed. Opt. 11(1) 014025 doi: 10.1117/1.2166370
Published in: Journal of Biomedical Optics Volume 11, Issue 1
Show Author Affiliations
Ute Jacobi, Charité-Univ. Medizin Berlin (Germany)
Marco Kaiser, Charité Univ. Hospital (Germany)
Jürgen Koscielny, Charité-Univ. Medizin Berlin (Germany)
Rijk Schuetz, Freie Univ. Berlin (Germany)
Martina C. Meinke, Charité-Univ. Medizin Berlin (Germany)
Wolfram Sterry, Charité-Univ. Medizin Berlin (Germany)
Jürgen Lademann, Charité-Univ. Medizin Berlin (Germany)

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