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Journal of Biomedical Optics

Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography
Author(s): Alexander Popp; Martina Wendel; Lilla Knels; T. Koch; Edmund Koch
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Paper Abstract

In this feasibility study, Fourier domain optical coherence tomography (FDOCT) is used for visualizing the 3-D structure of fixated lung parenchyma and to capture real-time cross sectional images of the subpleural alveolar mechanics in a ventilated and perfused isolated rabbit lung. The compact and modular setup of the FDOCT system allows us to image the first 500 µm of subpleural lung parenchyma with a 3-D resolution of 16×16×8 µm (in air). During mechanical ventilation, real-time cross sectional FDOCT images visualize the inflation and deflation of alveoli and alveolar sacks (acini) in successive images of end-inspiratory and end-expiratory phase. The FDOCT imaging shows the relation of local alveolar mechanics to the setting of tidal volume (VT), peak airway pressure, and positive end-expiratory pressure (PEEP). Application of PEEP leads to persistent recruitment of alveoli and acini in the end-expiratory phase, compared to ventilation without PEEP where alveolar collapse and reinflation are observed. The imaging of alveolar mechanics by FDOCT will help to determine the amount of mechanical stress put on the alveolar walls during tidal ventilation, which is a key factor in understanding the development of ventilator induced lung injury (VILI).

Paper Details

Date Published: 1 January 2006
PDF: 9 pages
J. Biomed. Opt. 11(1) 014015 doi: 10.1117/1.2162158
Published in: Journal of Biomedical Optics Volume 11, Issue 1
Show Author Affiliations
Alexander Popp, Technische Univ. Dresden (Germany)
Martina Wendel, Technische Univ. Dresden (Germany)
Lilla Knels, Technische Univ. Dresden (Germany)
T. Koch, Technische Univ. Dresden (Germany)
Edmund Koch, Technische Univ. Dresden (Germany)

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