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Journal of Biomedical Optics

Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer
Author(s): Vidi A. Saptari; Kamal Youcef-Toumi
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Paper Abstract

Near-infrared measurements of glucose in human plasma are performed using a custom, rapid, high-throughput filter-based spectrometer covering a spectral range between 2080 and 2315 nm. Quality of the measured glucose signals is quantified through the use of two figures of merit: selectivity and limit of detection. Selectivity measures the uniqueness of the glucose spectrum from among the interfering spectra. Limit of detection measures the smallest glucose concentration change detectable. The proposed system, which includes the spectroscopic hardware and a spectral preprocessing algorithm, is shown to produce a selectivity value of 0.57, with zero being nonselective and one being fully selective, and a limit of detection value of 2.2 mM. Prediction of an independent dataset is also performed using net analyte signal-based and partial least-squares multivariate calibration techniques, which produce standard error of prediction values of 1.14 and 1.45 mM, respectively.

Paper Details

Date Published: 1 November 2005
PDF: 9 pages
J. Biomed. Opt. 10(6) 064039 doi: 10.1117/1.2141934
Published in: Journal of Biomedical Optics Volume 10, Issue 6
Show Author Affiliations
Vidi A. Saptari, MKS Instruments, Inc. (United States)
Kamal Youcef-Toumi, Massachusetts Institute of Technology (United States)

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