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Journal of Biomedical Optics

Transcranial measurement of diffuse light reflectance from cold-injured brains in rats
Author(s): Yoshinori Ueda; Shunichi Sato; Hiroshi Ashida; Hidetoshi Ooigawa; Hiroshi Nawashiro; Katsuji Shima; Daizoh Saitoh; Yoshiaki Okada; Minoru Obara
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Paper Abstract

Diagnosis of brain edema is important to manage severe head injuries and diseases, but there is no method of noninvasive bedside monitoring of brain edema. We speculate that brain edema changes the optical properties of brain tissue. To verify this speculation, we perform transcranial measurement of diffuse light reflectance from cold-injured brains in rats. To induce edema, a liquid nitrogen-cooled copper probe of 3 mm diameter was applied to the right parietal bone for 60 s under anesthesia. The rat skull was irradiated with 633-nm HeNe laser light and 532-nm Nd:YVO4 laser light, which were used to investigate changes in light scattering and blood flow, respectively. Reflectance intensity was measured as functions of time and position on the skull. We found that reflectance intensities were significantly decreased around the cold injury at both 633 and 532 nm, while reflectance was increased in the cold injury at 532 nm, indicating that cerebral blood volume was decreased in the cold injury. Under the condition of decreased cerebral blood volume, the decrease in reflectance intensity around the injury suggests that the scattering coefficient of brain tissue was reduced due to edema formation in this area.

Paper Details

Date Published: 1 November 2005
PDF: 7 pages
J. Biomed. Opt. 10(6) 064010 doi: 10.1117/1.2136386
Published in: Journal of Biomedical Optics Volume 10, Issue 6
Show Author Affiliations
Yoshinori Ueda, Keio Univ. (Japan)
Shunichi Sato, National Defense Medical College (Japan)
Hiroshi Ashida, National Defense Medical College (Japan)
Hidetoshi Ooigawa, National Defense Medical College (Japan)
Hiroshi Nawashiro, National Defense Medical College (Japan)
Katsuji Shima, National Defense Medical College (Japan)
Daizoh Saitoh, National Defense Medical College (Japan)
Yoshiaki Okada, National Defense Medical College (Japan)
Minoru Obara, Keio Univ. (Japan)

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