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Journal of Biomedical Optics

Optoacoustic real-time dosimetry for selective retina treatment
Author(s): Georg Schuele; Hanno Elsner; Carsten Framme; Johann Roider; Reginald Birngruber; Ralf Brinkmann
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Paper Abstract

The selective retina treatment (SRT) targets retinal diseases associated with disorders in the retinal pigment epithelium (RPE). Due to the ophthalmoscopic invisibility of the laser-induced RPE effects, we investigate a noninvasive optoacoustic real-time dosimetry system. In vitro porcine RPE is irradiated with a Nd:YLF laser (527 nm, 1.7-µs pulse duration, 5 to 40 µJ, 30 pulses, 100-Hz repetition rate). Generated acoustic transients are measured with a piezoelectric transducer. During 27 patient treatments, the acoustic transients are measured with a transducer embedded in an ophthalmic contact lens. After treatment, RPE damage is visualized by fluorescein angiographic leakage. Below the RPE damage threshold, the optoacoustic transients show no pulse-to-pulse fluctuations within a laser pulse train. Above threshold, fluctuations of the individual transients among each other are observed. If optoacoustic pulse-to-pulse fluctuations are present, RPE leakage is observed in fluorescein angiography. In 96% of the irradiated areas, RPE leakage correlated with the optoacoustic defined threshold value. A noninvasive optoacoustic real-time dosimetry for SRT is developed and proved in vitro and during patient treatment. It detects the ophthalmoscopically invisible laser-induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice.

Paper Details

Date Published: 1 November 2005
PDF: 11 pages
J. Biomed. Opt. 10(6) 064022 doi: 10.1117/1.2136327
Published in: Journal of Biomedical Optics Volume 10, Issue 6
Show Author Affiliations
Georg Schuele, Lumenis, Inc. (United States)
Hanno Elsner, Univ. zu Lübeck (Germany)
Carsten Framme, Univ. Regensburg (Germany)
Johann Roider, Univ. of Kiel (Germany)
Reginald Birngruber, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Ralf Brinkmann, Univ. zu Lübeck (Germany)

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