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Journal of Biomedical Optics

Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy
Author(s): R. L. P. van Veen; Henricus J.C.M. Sterenborg; Antonio Pifferi; Alessandro Torricelli; Ekaterine Chikoidze; Rinaldo Cubeddu
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Paper Abstract

In-vivo optical spectroscopy and the determination of tissue absorption and scattering properties have a central role in the development of novel optical diagnostic and therapeutic modalities in medicine. A number of techniques are available for the optical characterization of tissue in the visible near-IR region of the spectrum. An important consideration for many of these techniques is the reliability of the absorption spectrum of the various constituents of tissue. The availability of accurate absorption spectra in the range 600 to 1100 nm may allow for the determination of the concentration of key tissue constituents such as oxy- and deoxy-hemoglobin, water, and lipids. The objective of the current study is the determination of a reliable absorption spectrum of lipid(s) that can be used for component analysis of in-vivo spectra. We report the absorption spectrum of a clear purified oil obtained from pig lard. In the liquid phase above 36°C, the oil is transparent and thus suitable for collimated transmission measurements. At room temperature, the oil is a solid grease that is highly scattering. The absorption and scattering properties in this solid phase are measured using time- and spatially resolved diffuse reflectance spectroscopy. Using these three independent measurement techniques, we have determined an accurate estimate for the absorption spectrum of mammalian fat.

Paper Details

Date Published: 1 September 2005
PDF: 6 pages
J. Biomed. Opt. 10(5) 054004 doi: 10.1117/1.2085149
Published in: Journal of Biomedical Optics Volume 10, Issue 5
Show Author Affiliations
R. L. P. van Veen, Univ. Medisch Ctr. Rotterdam (Netherlands)
Henricus J.C.M. Sterenborg, Univ. Medisch Ctr. Rotterdam (Netherlands)
Antonio Pifferi, Politecnico di Milano (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Ekaterine Chikoidze, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)


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