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Journal of Biomedical Optics

Enhancement of hidden structures of early skin fibrosis using polarization degree patterns and Pearson correlation analysis
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Paper Abstract

The skin of athymic nude mice is irradiated with a single dose of x-ray irradiation that initiated fibrosis. Digital photographs of the irradiated mice are taken by illuminating the mouse skin with linearly polarized probe light of 650 nm. The specific pattern of the surface distribution of the degree of polarization enables the detection of initial skin fibrosis structures that were not visually apparent. Data processing of the raw spatial distributions of the degree of polarization based on Fourier filtering of the high-frequency noise improves subjective perception of the revealed structure in the images. In addition, Pearson correlation analysis provides information about skin structural size and directionality.

Paper Details

Date Published: 1 September 2005
PDF: 6 pages
J. Biomed. Opt. 10(5) 051706 doi: 10.1117/1.2073727
Published in: Journal of Biomedical Optics Volume 10, Issue 5
Show Author Affiliations
Alexander P. Sviridov, National Institutes of Health (United States)
Victor V. Chernomordik, National Institutes of Health (United States)
Moinuddin Hassan, National Institutes of Health (United States)
Albert Claude Boccara, École Supérieure de Physique et de Chimie Industrielles (France)
Angelo Russo, National Institutes of Health (United States)
Paul D. Smith, National Institutes of Health (United States)
Amir H. Gandjbakhche, National Institutes of Health (United States)


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