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Journal of Biomedical Optics

Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study
Author(s): Natasha S. Shah; Jessica Gibbs; Dulcy E. Wolverton; Albert E. Cerussi; Nola M. Hylton; Bruce Jason Tromberg
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Paper Abstract

Monitoring tumor response to therapy can enable assessment of treatment efficacy, maximizing patient outcome and survival. We employ a noninvasive, handheld laser breast scanner (LBS) based on broadband diffuse optical spectroscopy (DOS) in conjunction with contrast-enhanced magnetic resonance imaging (cMRI) to assess tumor response to presurgical neoadjuvant chemotherapy. DOS and cMRI scans are performed after the first and fourth cycles of a doxorubicin/cyclophosphamide regimen in a patient with invasive ductal carcinoma. DOS measurements are used to quantify bulk tissue optical and physiological parameters, which are mapped to T2- and T1-weighted cMRI images. Initial DOS measurements show high tumor/normal contrast in total hemoglobin concentration (THC, 56±7 versus 27±4 µM) and water fraction (81.4±1% versus 24±3%) colocalized with regions of strongly enhancing T2-wieghted and cMRI signals. After the fourth cycle of chemotherapy, we observe decreases in peak MRI contrast-enhancement values (37.6%) and apparent lesion volume (21.9 versus 13.7 cm3), which corresponds to physiological changes measured by DOS, including a 20 to 25% reduction in the spatial extent of the tumor and a 38.7% drop in mean total hemoglobin content (THC, 41.6 versus 23.4 µM). These data provide in vivo validation of the accuracy of broadband DOS and the sensitivity of optical methods to changes in tumor physiology.

Paper Details

Date Published: 1 September 2005
PDF: 9 pages
J. Biomed. Opt. 10(5) 051503 doi: 10.1117/1.2070147
Published in: Journal of Biomedical Optics Volume 10, Issue 5
Show Author Affiliations
Natasha S. Shah, Univ. of California/Irvine (United States)
Jessica Gibbs, Univ. of California/Irvine (United States)
Dulcy E. Wolverton, Univ. of California/Irvine (United States)
Albert E. Cerussi, Univ. of California/Irvine (United States)
Nola M. Hylton, Univ. of California/San Francisco (United States)
Bruce Jason Tromberg, Univ. of California/Irvine (United States)

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