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Journal of Biomedical Optics

Near-infrared fiber optic spectroscopy as a novel diagnostic tool for the detection of pancreatic cancer
Author(s): Venkata R. Kondepati; Johann Zimmermann; Michael Keese; Joerg Sturm; Bernd Christoph Manegold; Juergen Backhaus
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Paper Abstract

We have investigated the application of near-infrared (NIR) fiber-optic spectroscopy for the diagnosis of pancreatic cancer. Cluster analysis of the Fourier transformed near-infrared (FTNIR) fiber-optic spectra of surgically resected pancreatic tumor tissues allowed discrimination of tumor from normal tissue with high sensitivity and specificity. The sensitivity of the method using spectral information of the CH stretching first overtone region (5951–5608 cm–1) was 83.3% with a specificity of 83.3%. Based on the CH stretching second overtone region (8605–7938 cm–1) we could achieve a sensitivity of 88.9% and specificity of 72.2%. These findings suggest that NIR spectroscopy offers the potential for minimally invasive in-vivo diagnosis of pancreatic cancer.

Paper Details

Date Published: 1 September 2005
PDF: 6 pages
J. Biomed. Opt. 10(5) 054016 doi: 10.1117/1.2060568
Published in: Journal of Biomedical Optics Volume 10, Issue 5
Show Author Affiliations
Venkata R. Kondepati, Fachhochschule Mannheim (Germany)
Johann Zimmermann, Fachhochschule Mannheim (Germany)
Michael Keese, Univ. Heidelberg (Germany)
Joerg Sturm, Univ. Heidelberg (Germany)
Bernd Christoph Manegold, Univ. Heidelberg (Germany)
Juergen Backhaus, Fachhochschule Mannheim (Germany)


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