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Journal of Biomedical Optics

Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging
Author(s): Robert M. Hoffman
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Paper Abstract

The revolution of in vivo cancer biology enabled by fluorescent proteins is described. The high extinction coefficients, quantum yields, and unique spectral properties of fluorescent proteins have been taken advantage of in order to visualize, in real time, the important aspects of cancer in living animals, including tumor cell trafficking, invasion, metastasis, and angiogenesis. Fluorescent proteins enable whole-body imaging of tumors on internal organs. These multicolored proteins have allowed the color-coding of cancer cells growing in vivo with distinction of different cell types, including host from tumor, with single-cell resolution.

Paper Details

Date Published: 1 July 2005
PDF: 10 pages
J. Biomed. Opt. 10(4) 041202 doi: 10.1117/1.1992485
Published in: Journal of Biomedical Optics Volume 10, Issue 4
Show Author Affiliations
Robert M. Hoffman, AntiCancer, Inc. (United States)


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