Share Email Print
cover

Journal of Biomedical Optics

Differences in optical properties between healthy and pathological human colon tissues using a Ti:sapphire laser: an in vitro study using the Monte Carlo inversion technique
Author(s): Huajiang Wei; Da Xing; Guoyong Wu; Huaimin Gu; Jianjun Lu; Ying Jin; Xiao-Yuan Li
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The purpose of the study is to analyze and compare differences in the optical properties between normal and adenomatous human colon tissues in vitro at 630-, 680-, 720-, 780-, 850-, and 890-nm wavelengths using a Ti:sapphire laser. The optical parameters of tissue samples are determined using a double integrating sphere setup at seven different laser wavelengths. The inverse Monte Carlo simulation is used to determine the optical properties from the measurements. The results of measurement show that the optical properties and their differences vary with a change of laser wavelength for normal and adenomatous colon mucosa/submucosa and normal and adenomatous colon muscle layer/chorion. The maximum absorption coefficients for normal and adenomatous human colon mucosa/submucosa are 680 nm, and the minimum absorption coefficients for both are 890 nm. The maximum difference of the absorption coefficients between both is 56.8% at 780 nm. The maximum scattering coefficients for normal and adenomatous colon mucosa/submucosa are 890 nm, and the minimum scattering coefficients for both are 780 nm. The maximum difference of the scattering coefficients between both is 10.6% at 780 nm. The maximum absorption coefficients for normal and adenomatous colon muscle layer/chorion are 680 nm, and the minimum absorption coefficients for both are 890 nm. The maximum difference of the absorption coefficients between both is 47.9% at 780 nm. The maximum scattering coefficients for normal and adenomatous colon muscle layer/chorion are 890 nm, and the minimum scattering coefficients for both are 680 nm. The maximum difference of the scattering coefficients between both is 9.61% at 850 nm. The differences in absorption coefficients between normal and adenomatous tissues are more significant than those in scattering coefficients.

Paper Details

Date Published: 1 July 2005
PDF: 7 pages
J. Biomed. Opt. 10(4) 044022 doi: 10.1117/1.1990125
Published in: Journal of Biomedical Optics Volume 10, Issue 4
Show Author Affiliations
Huajiang Wei, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)
Guoyong Wu, Sun Yat-Sen Univ. (China)
Huaimin Gu, South China Normal Univ. (China)
Jianjun Lu, Sun Yat-Sen Univ. (China)
Ying Jin, South China Normal Univ. (China)
Xiao-Yuan Li, South China Normal Univ. (China)


© SPIE. Terms of Use
Back to Top