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Journal of Biomedical Optics

Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators
Author(s): Melissa J. Suter; Geoffrey McLennan; Joseph M. Reinhardt; Paul R. Montague; Peter Taft; John Lee; Joseph Zabner
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Paper Abstract

In current clinical practice, the initial stage in the detection of pulmonary airway disease is the clinician's interpretation of a bronchoscopy procedure. Due to the nature of this form of detection, diseases are often well advanced upon discovery. This paper proposes a new method for examining the pulmonary airway microcirculatory system via fluorescein imaging techniques similar to those used extensively in ophthalmology. Through the use of a specialized bronchoscopy imaging system we are able to successfully show that fluorescein emission detected in the rabbit trachea exhibits a clear response to inflammatory mediators and thus to changing local vascularity. The clinical implications of this technique are extensive including most importantly the potential use as an evaluation tool for pulmonary disease evaluation and likely other endoscopically accessible organs.

Paper Details

Date Published: 1 May 2005
PDF: 5 pages
J. Biomed. Opt. 10(3) 034013 doi: 10.1117/1.1924714
Published in: Journal of Biomedical Optics Volume 10, Issue 3
Show Author Affiliations
Melissa J. Suter, Univ. of Iowa Hospitals and Clinics (United States)
Geoffrey McLennan, Univ. of Iowa Hospitals and Clinics (United States)
Joseph M. Reinhardt, The Univ. of Iowa (United States)
Paul R. Montague, Univ. of Iowa Hospitals and Clinics (United States)
Peter Taft, Univ. of Iowa Hospitals and Clinics (United States)
John Lee, Univ. of Iowa Hospitals and Clinics (United States)
Joseph Zabner, Univ. of Iowa Hospitals and Clinics (United States)


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