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Journal of Biomedical Optics

Effect of hemoglobin concentration variation on the accuracy and precision of glucose analysis using tissue modulated, noninvasive, in vivo Raman spectroscopy of human blood: a small clinical study
Author(s): Joseph Chaiken; William F. Finney; Paul E. Knudson; Ruth S. Weinstock; Muhktar Khan; Rebecca Jane Bussjager; Douglas Hagrman; Pamela Hagrman; Yiwei Zhao; Charles M. Peterson; Karen P. Peterson
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Paper Abstract

Tissue modulated Raman spectroscopy was used noninvasively to measure blood glucose concentration in people with type I and type II diabetes with HemoCue fingerstick measurements being used as reference. Including all of the 49 measurements, a Clarke error grid analysis of the noninvasive measurements showed that 72% were A range, i.e., clinically accurate, 20% were B range, i.e., clinically benign, with the remaining 8% of measurements being essentially erroneous, i.e., C, D, or E range. Rejection of 11 outliers gave a correlation coefficient of 0.80, a standard deviation of 22 mg/dL with p<0.0001 for N=38 and places all but one of the measurements in the A and B ranges. The distribution of deviations of the noninvasive glucose measurements from the fingerstick glucose measurements is consistent with the suggestion that there are at least two systematic components in addition to the random noise associated with shot noise, charge coupled device spiking, and human factors. One component is consistent with the known variation of fingerstick glucose concentration measurements from laboratory reference measurements made using plasma or whole blood. A weak but significant correlation between the deviations of noninvasive measurements from fingerstick glucose measurements and the test subject's hemoglobin concentration was also observed.

Paper Details

Date Published: 1 May 2005
PDF: 12 pages
J. Biomed. Opt. 10(3) 031111 doi: 10.1117/1.1922147
Published in: Journal of Biomedical Optics Volume 10, Issue 3
Show Author Affiliations
Joseph Chaiken, Syracuse Univ. (United States)
William F. Finney, Univ. of Michigan (United States)
Paul E. Knudson, Upstate Medical Univ./SUNY (United States)
Ruth S. Weinstock, Upstate Medical Univ./SUNY (United States)
Muhktar Khan, Upstate Medical Univ./SUNY (United States)
Rebecca Jane Bussjager, Air Force Research Lab. (United States)
Douglas Hagrman, LighTouch Medical, Inc. (United States)
Pamela Hagrman, LighTouch Medical, Inc. (United States)
Yiwei Zhao, LighTouch Medical, Inc. (United States)
Charles M. Peterson, LighTouch Medical, Inc. (United States)
Karen P. Peterson, National Institutes of Health (United States)


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