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Journal of Biomedical Optics

Raman spectroscopy for noninvasive glucose measurements
Author(s): Annika M.K. Enejder; Thomas G. Scecina; Jeankun Oh; Martin Hunter; WeiChuan Shih; Slobodan Sasic; Gary L. Horowitz; Michael S. Feld
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Paper Abstract

We report the first successful study of the use of Raman spectroscopy for quantitative, noninvasive ("transcutaneous") measurement of blood analytes, using glucose as an example. As an initial evaluation of the ability of Raman spectroscopy to measure glucose transcutaneously, we studied 17 healthy human subjects whose blood glucose levels were elevated over a period of 2–3 h using a standard glucose tolerance test protocol. During the test, 461 Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation. The mean absolute errors for each subject were 7.8%±1.8% (mean±std) with R2 values of 0.83±0.10. We provide spectral evidence that the glucose spectrum is an important part of the calibrations by analysis of the calibration regression vectors.

Paper Details

Date Published: 1 May 2005
PDF: 9 pages
J. Biomed. Opt. 10(3) 031114 doi: 10.1117/1.1920212
Published in: Journal of Biomedical Optics Volume 10, Issue 3
Show Author Affiliations
Annika M.K. Enejder, Chalmers Tekniska Högskola (Sweden)
Thomas G. Scecina, Massachusetts Institute of Technology (United States)
Jeankun Oh, Massachusetts Institute of Technology (United States)
Martin Hunter, Massachusetts Institute of Technology (United States)
WeiChuan Shih, Massachusetts Institute of Technology (United States)
Slobodan Sasic, Massachusetts Institute of Technology (United States)
Gary L. Horowitz, Beth Israel Deaconess Medical Ctr. (United States)
Michael S. Feld, Massachusetts Institute of Technology (United States)

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