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Journal of Biomedical Optics

Glucose determination in human aqueous humor with Raman spectroscopy
Author(s): James L. Lambert; Christine C. Pelletier; Mark S. Borchert
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Paper Abstract

It has been suggested that spectroscopic analysis of the aqueous humor of the eye could be used to indirectly predict blood glucose levels in diabetics noninvasively. We have been investigating this potential using Raman spectroscopy in combination with partial least squares (PLS) analysis. We have determined that glucose at clinically relevant concentrations can be accurately predicted in human aqueous humor in vitro using a PLS model based on artificial aqueous humor. We have further determined that with proper instrument design, the light energy necessary to achieve clinically acceptable prediction of glucose does not damage the retinas of rabbits and can be delivered at powers below internationally acceptable safety limits. Herein we summarize our current results and address our strategies to improve instrument design.

Paper Details

Date Published: 1 May 2005
PDF: 8 pages
J. Biomed. Opt. 10(3) 031110 doi: 10.1117/1.1914843
Published in: Journal of Biomedical Optics Volume 10, Issue 3
Show Author Affiliations
James L. Lambert, Jet Propulsion Lab. (United States)
Christine C. Pelletier, Jet Propulsion Lab. (United States)
Mark S. Borchert, Univ. of Southern California (United States)

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