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Journal of Biomedical Optics

Experimental study on the healing process following laser welding of the cornea
Author(s): Francesca Rossi; Roberto Pini; Luca Menabuoni; Rita Mencucci; Ugo Menchini; Stefano Ambrosini; Gabriella Vannelli
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Paper Abstract

An experimental study evaluating the application of laser welding of the cornea and the subsequent healing process is presented. The welding of corneal wounds is achieved after staining the cut walls with a solution of the chromophore indocyanine green, and irradiating them with a diode laser (810 nm) operating at low power (60 to 90 mW). The result is a localized heating of the cut, inducing controlled welding of the stromal collagen. In order to optimize this technique and to study the healing process, experimental tests, simulating cataract surgery and penetrating keratoplasty, were performed on rabbits: conventional and laser-induced suturing of corneal wounds were thus compared. A follow-up study 7 to 90 days after surgery was carried out by means of objective and histological examinations, in order to optimize the welding technique and to investigate the subsequent healing process. The analyses of the laser-welded corneas evidenced a faster and more effective restoration of the architecture of the stroma. No thermal damage of the welded stroma was detected, nor were there foreign body reactions or other inflammatory processes.

Paper Details

Date Published: 1 March 2005
PDF: 7 pages
J. Biomed. Opt. 10(2) 024004 doi: 10.1117/1.1900703
Published in: Journal of Biomedical Optics Volume 10, Issue 2
Show Author Affiliations
Francesca Rossi, IFAC-CNR (Italy)
Roberto Pini, IFAC-CNR (Italy)
Luca Menabuoni, Istituto di Fisica Applicata (Italy)
Rita Mencucci, Univ. degli Studi di Firenze (Italy)
Ugo Menchini, Univ. degli Studi di Firenze (Italy)
Stefano Ambrosini, Univ. degli Studi di Firenze (Italy)
Gabriella Vannelli, Univ. degli Studi di Firenze (Italy)

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