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Journal of Biomedical Optics • Open Access

Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels
Author(s): Kun Chen; Yang Liu; Guillermo Ameer; Vadim Backman

Paper Abstract

Optical molecular imaging could potentially enable noninvasive high-resolution characterization and diagnosis of living tissue. The capability to image multiple molecular targets simultaneously is particularly important. Currently this task cannot be achieved using conventional optical contrast agents, due to their broad spectral responses (~80 to 200 nm). Developments in research on semiconductor nanocrystals (quantum dots) provide one possible solution. We describe a different concept of multilabel molecular imaging that utilizes resonant light-scattering spectroscopy of multilayered nanospheres to achieve tunable ultrasharp resonance peaks with widths as narrow as 10 nm. Our theoretical study demonstrates that dozens of molecular targets can potentially be imaged simultaneously using this approach.

Paper Details

Date Published: 1 March 2005
PDF: 6 pages
J. Biomed. Opt. 10(2) 024005 doi: 10.1117/1.1899684
Published in: Journal of Biomedical Optics Volume 10, Issue 2
Show Author Affiliations
Kun Chen, Northwestern Univ. (United States)
Yang Liu, Northwestern Univ. (United States)
Guillermo Ameer, Northwestern Univ. (United States)
Vadim Backman, Northwestern Univ. (United States)

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