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Journal of Biomedical Optics

Coregistered tomographic x-ray and optical breast imaging: initial results
Author(s): Quan Zhang; Thomas J. Brukilacchio; Ang Li; Jonathan J. Stott; Tina Chaves; Elizabeth M. C. Hillman; Tao Wu; MaryAnn Chorlton; Elizabeth A. Rafferty; Richard H. Moore; Daniel B. Kopans; David A. Boas
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Paper Abstract

We describe what is, to the best of our knowledge, the first pilot study of coregistered tomographic x-ray and optical breast imaging. The purpose of this pilot study is to develop both hardware and data processing algorithms for a multimodality imaging method that provides information that neither x-ray nor diffuse optical tomography (DOT) can provide alone. We present in detail the instrumentation and algorithms developed for this multimodality imaging. We also present results from our initial pilot clinical tests. These results demonstrate that strictly coregistered x-ray and optical images enable a detailed comparison of the two images. This comparison will ultimately lead to a better understanding of the relationship between the functional contrast afforded by optical imaging and the structural contrast provided by x-ray imaging.

Paper Details

Date Published: 1 March 2005
PDF: 9 pages
J. Biomed. Opt. 10(2) 024033 doi: 10.1117/1.1899183
Published in: Journal of Biomedical Optics Volume 10, Issue 2
Show Author Affiliations
Quan Zhang, Massachusetts General Hospital (United States)
Thomas J. Brukilacchio, Innovations in Optics, Inc. (United States)
Ang Li, Tufts Univ. (United States)
Jonathan J. Stott, Massachusetts General Hospital (United States)
Tina Chaves, Massachusetts General Hospital (United States)
Elizabeth M. C. Hillman, Massachusetts General Hospital (United States)
Tao Wu, Massachusetts General Hospital (United States)
MaryAnn Chorlton, Massachusetts General Hospital (United States)
Elizabeth A. Rafferty, Massachusetts General Hospital (United States)
Richard H. Moore, Massachusetts General Hospital (United States)
Daniel B. Kopans, Massachusetts General Hospital (United States)
David A. Boas, Massachusetts General Hospital (United States)


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