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Journal of Biomedical Optics

Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer
Author(s): Changfang Zhu; Gregory M. Palmer; Tara M. Breslin; Fushen Xu; Nirmala Ramanujam
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Paper Abstract

We explore the effects of the illumination and collection geometry on optical spectroscopic diagnosis of breast cancer. Fluorescence and diffuse reflectance spectroscopy in the UV-visible spectral range are made with a multiseparation probe at three illumination-collection separations of 735, 980, and 1225 µm, respectively, from 13 malignant and 34 nonmalignant breast tissues. Statistical analysis is carried out on two types of data inputs: (1) the fluorescence and diffuse reflectance spectra recorded at each of the three illumination-collection separations and (2) the integrated fluorescence (at each excitation wavelength) or diffuse reflectance over the entire spectrum at all three illumination-collection separations. The results show that using the integrated fluorescence intensities recorded at a single excitation wavelength at all three illumination-collection separations can discriminate malignant from nonmalignant breast tissues with similar classification accuracy to that using spectral data measured at several excitation wavelengths with a single illumination-collection separation. These findings have significant implications with respect to the design of an optical system for breast cancer diagnosis. Examining the intensity attenuation at a single wavelength rather than spectral intensities at multiple wavelengths can significantly reduce the measurement and data processing time in a clinical setting as well as the cost and complexity of the optical system.

Paper Details

Date Published: 1 March 2005
PDF: 13 pages
J. Biomed. Opt. 10(2) 024032 doi: 10.1117/1.1897398
Published in: Journal of Biomedical Optics Volume 10, Issue 2
Show Author Affiliations
Changfang Zhu, Univ. of Wisconsin/Madison (United States)
Gregory M. Palmer, Univ. of Wisconsin/Madison (United States)
Tara M. Breslin, Univ. of Wisconsin/Madison (United States)
Fushen Xu, Univ. of Wisconsin (United States)
Nirmala Ramanujam, Univ. of Wisconsin/Madison (United States)

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