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Journal of Biomedical Optics

Diffraction-free acoustic detection for optoacoustic depth profiling of tissue using an optically transparent polyvinylidene fluoride pressure transducer operated in backward and forward mode
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Paper Abstract

An optoacoustic detection method suitable for depth profiling of optical absorption of layered or continuously varying tissue structures is presented. Detection of thermoelastically induced pressure transients allows reconstruction of optical properties of the sample to a depth of several millimeters with a spatial resolution of 24 µm. Acoustic detection is performed using a specially designed piezoelectric transducer, which is transparent for optical radiation. Thus, ultrasonic signals can be recorded at the same position the tissue is illuminated. Because the optoacoustical sound source is placed in the pulsed-acoustic near field of the pressure sensor, signal distortions commonly associated with acoustical diffraction are eliminated. Therefore, the acoustic signals mimic exactly the depth profile of the absorbed energy. This is illustrated by imaging the absorption profile of a two-layered sample with different absorption coefficients, and of a dye distribution while diffusing into a gelatin phantom.

Paper Details

Date Published: 1 March 2005
PDF: 7 pages
J. Biomed. Opt. 10(2) 024035 doi: 10.1117/1.1891443
Published in: Journal of Biomedical Optics Volume 10, Issue 2
Show Author Affiliations
Michael Jaeger, Univ. Bern (Switzerland)
Joel Niederhauser, Univ. Bern (Switzerland)
Marjaneh Hejazi, Univ. Bern (Switzerland)
Martin Frenz, Univ. Bern (Switzerland)

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