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Journal of Biomedical Optics

In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy
Author(s): Jun Zhao; Hai Shu Ding; Xinling Hou; Congle Zhou; Britton Chance
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Paper Abstract

We investigate the optical properties of the brain in 23 neonates in vivo using a frequency domain near-infrared spectroscopy (NIRS). In this study, a calibration procedure is employed to determine the absorption and reduced scattering coefficients with single source-detector separation. The absorption coefficients of the infant foreheads are lower than the values reported in adults. A large intersubject variation in the reduced scattering coefficients is also demonstrated. Furthermore, physiological parameters are derived from the absorption coefficients at two wavelengths (788 and 832 nm). The mean total hemoglobin concentration (THC) is 39.7±9.8 µM and the mean cerebral blood oxygen saturation (StO2) is 58.7±11.2%. Our preliminary results show that this bedside frequent domain NIRS could provide quantitative optical measurement of the infant brain.

Paper Details

Date Published: 1 March 2005
PDF: 7 pages
J. Biomed. Opt. 10(2) 024028 doi: 10.1117/1.1891345
Published in: Journal of Biomedical Optics Volume 10, Issue 2
Show Author Affiliations
Jun Zhao, Tsinghua Univ. (China)
Hai Shu Ding, Tsinghua Univ. (China)
Xinling Hou, First Hospital of Peking Univ. (China)
Congle Zhou, First Hospital of Peking Univ. (China)
Britton Chance, Univ. of Pennsylvania (United States)

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