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Journal of Biomedical Optics

Synergy effects between organic and inorganic UV filters in sunscreens
Author(s): Jürgen Lademann; S. Schanzer; Ute Jacobi; H. Schaefer; F. Pflücker; H. Driller; J. Beck; M. Meinke; Andre Roggan; Wolfram Sterry
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Paper Abstract

The influence of the synergy effects between organic and inorganic UV filter substances on the sun protection factor (SPF) of topically applied sunscreen formulations is investigated. The medium is considered to have reflection, absorption, and scattering properties. The distribution of photons in this medium is investigated by Monte Carlo calculation. Typical optical parameters of the skin and substances are used to characterize the synergy effect. The results of the model calculation are checked by in vitro and in vivo measurements investigating the influence of different types of scattering microparticles on the absorption efficacy of topically applied formulations. It is found that the inorganic filter substances act as scattering microparticles in the upper skin layers. They increase the optical pathway of the photons in the topically applied absorbing formulation also localized there. In this way, more photons are absorbed, increasing the SPF. The results obtained are important for the optimization of the SPF of sunscreen formulation containing organic and inorganic UV-filter components.

Paper Details

Date Published: 1 January 2005
PDF: 7 pages
J. Biomed. Opt. 10(1) 014008 doi: 10.1117/1.1854112
Published in: Journal of Biomedical Optics Volume 10, Issue 1
Show Author Affiliations
Jürgen Lademann, Charité-Univ. Medizin Berlin (Germany)
S. Schanzer, Charité Univ. Hospital (Germany)
Ute Jacobi, Charité Univ. Hospital (Germany)
H. Schaefer, Charité Univ. Hospital (Germany)
F. Pflücker, MERCK KGaA (Germany)
H. Driller, Merck KGaA Darmstadt (Germany)
J. Beck, Merck KGaA Darmstadt (Germany)
M. Meinke, Laser- und Medizintechnik GmbH (Germany)
Andre Roggan, Laser und Medizin Technologie gGmbH Berlin (Germany)
Wolfram Sterry, Charite Univ. Hospital (Germany)

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