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Journal of Biomedical Optics

Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study
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Paper Abstract

The letter-fluency task-induced response over the prefrontal cortex is investigated bilaterally on eight subjects using a recently developed compact, eight-channel, time-resolved, near-IR system. The cross-subject mean values of prefrontal cortex oxygen saturation (SO2) were 68.8±3.2% (right) and 71.0±3.6% (left), and of total hemoglobin concentration (tHb) were 69.6±9.6 µM (right) and 69.5±9.9 µM (left). The typical cortical activation response to the cognitive task [characterized by an increase in oxyhemoglobin (O2Hb) with a concurrent decrease in deoxyhemoglobin (HHb)] at each measurement point is observed in only four subjects. In this subset, the amplitude of the O2Hb increase and HHb decrease is uniform over each prefrontal cortex area and comparable between the two hemispheres. These findings agree with previous studies using continuous wave functional near-IR spectroscopy and functional magnetic resonance imaging, therefore demonstrating the potential of a time-resolved spectroscopy approach. In addition, a significant increase in SO2 levels was observed in the right (1.1±0.5%) compared to left side of the prefrontal cortex (0.9±0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects.

Paper Details

Date Published: 1 January 2005
PDF: 12 pages
J. Biomed. Opt. 10(1) 011012 doi: 10.1117/1.1851512
Published in: Journal of Biomedical Optics Volume 10, Issue 1
Show Author Affiliations
Valentina Quaresima, Univ. degli Studi dell'Aquila (Italy)
Marco Ferrari, Univ. degli Studi dell'Aquila (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Lorenzo Spinelli, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)

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