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Journal of Biomedical Optics

Accurate measurement of blood vessel depth in port wine stained human skin in vivo using pulsed photothermal radiometry
Author(s): Bincheng Li; Boris Majaron; John A. Viator; Thomas E. Milner; Zhongping Chen; Yonghua Zhao; Hongwu Ren; John Stuart Nelson
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Paper Abstract

We report on application of pulsed photothermal radiometry (PPTR) to determine the depth of port wine stain (PWS) blood vessels in human skin. When blood vessels are deep in the PWS skin (<100 μm), conventional PPTR depth profiling can be used to determine PWS depth with sufficient accuracy. When blood vessels are close or partially overlap the epidermal melanin layer, a modified PPTR technique using two-wavelength (585 and 600 nm) excitation is a superior method to determine PWS depth. A direct difference approach in which PWS depth is determined from a weighted difference of temperature profiles reconstructed independently from two-wavelength excitation is demonstrated to be appropriate for a wider range of PWS patients with various blood volume fractions, blood vessel sizes, and depth distribution. The most superficial PWS depths determined in vivo by PPTR are in good agreement with those measured using optical Doppler tomography (ODT).

Paper Details

Date Published: 1 September 2004
PDF: 6 pages
J. Biomed. Opt. 9(5) doi: 10.1117/1.1784470
Published in: Journal of Biomedical Optics Volume 9, Issue 5
Show Author Affiliations
Bincheng Li, Univ. of California (United States)
Boris Majaron, Institute Jozef Stefan (Slovenia)
John A. Viator, Univ. of Missouri/Columbia (United States)
Thomas E. Milner, Univ. of Texas/Austin (United States)
Zhongping Chen, Univ. of California/Irvine (United States)
Yonghua Zhao, Univ. of California/Irvine (United States)
Hongwu Ren, California Institute of Technology (United States)
John Stuart Nelson, Univ. of California/Irvine (United States)


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